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Goodman and Gilman's The Pharmacological Basis of Therapeutics

A Doody's Core Title for 2023! The landmark pharmacology reference—updated to reflect the latest research and developments in the field For more than 50 years, Goodman & Gilman’s: The Pharmacological Basis of Therapeutics has represented the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. The text's careful balance of basic science and clinical applications has guided thousands of health care practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing and treating disease. This Fourteenth Edition includes five new chapters, 600+ illustrations, and important content from 53 new contributors. More than a textbook, Goodman & Gilman’s is a working template for the effective and rational prescribing of drugs in daily practice. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, Fourteenth Edition features: Five NEW chapters on: -Pharmacovigilance -The blood-brain barrier -Cannabis -Antibodies, immune checkpoint inhibitors, CAR-T cells, and other biological agents -Gastrointestinal microbiome and drug response Expanded coverage of the use of genetic polymorphisms in designing appropriate therapies Revised and expanded chapter on pharmacodynamics and the molecular mechanisms of drug action 600+ color illustrations Drug Fact Tables summarizing clinical pharmacology Content Outline and Abbreviation List at the beginning of each chapter 50 NEW figures on mechanism of drug actions 53 NEW contributors NEW online updates

Goodman and Gilman's The Pharmacological Basis of Therapeutics
    Información general
  • Formato Impreso
  • Acabado Tapa Dura
  • Año de publicación 2022
  • Editorial Mcgraw Hill Inglés
  • Autor Brunton, L.
  • Páginas 1664
  • ISBN 9781264258079
  • Edición 14ª
  • Precio Lista USD $ 193
  • Precio Lista USD $ 193
  • Precio CELSUS USD $ 164
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A Doody's Core Title for 2023! The landmark pharmacology reference—updated to reflect the latest research and developments in the field For more than 50 years, Goodman & Gilman’s: The Pharmacological Basis of Therapeutics has represented the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. The text's careful balance of basic science and clinical applications has guided thousands of health care practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing and treating disease. This Fourteenth Edition includes five new chapters, 600+ illustrations, and important content from 53 new contributors. More than a textbook, Goodman & Gilman’s is a working template for the effective and rational prescribing of drugs in daily practice. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, Fourteenth Edition features: Five NEW chapters on: -Pharmacovigilance -The blood-brain barrier -Cannabis -Antibodies, immune checkpoint inhibitors, CAR-T cells, and other biological agents -Gastrointestinal microbiome and drug response Expanded coverage of the use of genetic polymorphisms in designing appropriate therapies Revised and expanded chapter on pharmacodynamics and the molecular mechanisms of drug action 600+ color illustrations Drug Fact Tables summarizing clinical pharmacology Content Outline and Abbreviation List at the beginning of each chapter 50 NEW figures on mechanism of drug actions 53 NEW contributors NEW online updates

Section I

General Principles 1

  1. Drug Discovery: From Medicinal Plants to Computer-Aided

Drug Design ........................................................................................... 3

Michael K. Gilson and Laurence L. Brunton

  1. Pharmacokinetics: The Dynamics of Drug Absorption,

Distribution, Metabolism, and Elimination ..................................... 23

Iain L. O. Buxton

  1. Pharmacodynamics: Molecular Mechanisms of Drug Action....... 43

David R. Manning and Donald K. Blumenthal

  1. Membrane Transporters and Drug Response .................................. 79

Kathleen M. Giacomini and Yuichi Sugiyama

  1. Drug Metabolism ............................................................................... 101

Frank J. Gonzalez and Michael Coughtrie

  1. The Gastrointestinal Microbiome and Drug Response ................ 119

Shirley M. Tsunoda, Pieter C. Dorrestein, and Rob Knight

  1. Pharmacogenetics and Pharmacogenomics................................... 131

Dan M. Roden and Sara L. Van Driest

  1. Postmarketing Drug Safety............................................................... 145
  2. Michael Stein and Wayne A. Ray
  3. Principles of Clinical Toxicology ..................................................... 155

Amberly R. Johnson and Kaitlyn M. Brown

Section II

Neuropharmacology 171

  1. Neurotransmission: The Autonomic and Somatic Motor

Nervous Systems ................................................................................ 173

Rebecca Petre Sullivan, Steven R. Houser, and Walter J. Koch

  1. Muscarinic Receptor Agonists and Antagonists............................ 207

Joan Heller Brown, Katharina Brandl, and Jürgen Wess

  1. Anticholinesterase Inhibitors and Reactivators............................. 221

Palmer Taylor

  1. Neuromuscular Junction and Autonomic Ganglia; Nicotine,

Muscle Relaxants, and Spasmolytics ............................................... 235

Ryan E. Hibbs and Alexander C. Zambon

  1. Adrenergic Agonists and Antagonists............................................. 251

Douglas G. Tilley, Steven R. Houser, and Walter J. Koch

  1. 5-Hydroxytryptamine (Serotonin) and Dopamine ....................... 285

Charles D. Nichols, Susan G. Amara, and David R. Sibley

  1. Neurotransmission in the Central Nervous System...................... 305
  2. Benjamin Free, Suzanne M. Underhill, Susan G. Amara,

and David R. Sibley

  1. The Blood-Brain Barrier and Its Influence on Drug

Transport to the Brain ....................................................................... 327

Richard Daneman, Margareta Hammarlund-Udenaes,

and Eric V. Shusta

  1. Drug Therapy of Depression and Anxiety Disorders.................... 343

James M. O’Donnell, Robert R. Bies, and Aislinn J. Williams

  1. Pharmacotherapy of Psychosis and Mania ..................................... 357

Jonathan M. Meyer

  1. Pharmacotherapy of the Epilepsies.................................................. 385

Cameron S. Metcalf, Misty D. Smith, and Karen S. Wilcox

  1. Treatment of Central Nervous System

Degenerative Disorders..................................................................... 413

Erik D. Roberson and Talene A. Yacoubian

  1. Hypnotics and Sedatives.................................................................... 427
  2. John Mihic and Jody Mayfield
  3. Opioid Analgesics ............................................................................. 443

Emily M. Jutkiewicz and John R. Traynor

  1. General Anesthetics and Therapeutic Gases.................................. 471

Jerry Ingrande, Matthew L. Pearn, and Hemal H. Patel

  1. Local Anesthetics............................................................................... 489

William A. Catterall and Kenneth Mackie

  1. Cannabinoids...................................................................................... 505

Matthew N. Hill and Kenneth Mackie

  1. Ethanol................................................................................................. 519

Jody Mayfield and S. John Mihic

  1. Drug Use Disorders and Addiction................................................. 531

Christine Konradi and Yasmin L. Hurd

Section III

Modulation of Pulmonary, Renal,

and Cardiovascular 555

  1. Drugs Affecting Renal Excretory Function.................................... 557

Edwin K. Jackson

  1. Renin and Angiotensin...................................................................... 585

Krishna Sriram and Paul A. Insel

  1. Treatment of Ischemic Heart Disease.............................................. 607

Thomas Eschenhagen

  1. Treatment of Hypertension............................................................... 625

Thomas Eschenhagen

  1. Therapy of Heart Failure ................................................................... 647

Thomas Eschenhagen

  1. Antiarrhythmic Drugs....................................................................... 667

Bjorn C. Knollmann, Dan M. Roden, and Katherine T. Murray

  1. Treatment of Pulmonary Arterial Hypertension ........................... 695

Dustin R. Fraidenburg, Ankit A. Desai, Ayako Makino,

and Jason X.-J. Yuan

  1. Blood Coagulation and Anticoagulant, Fibrinolytic, and

Antiplatelet Drugs.............................................................................. 709

Jeffrey I. Weitz

  1. Drug Therapy for Dyslipidemias..........................................

viii Section IV

Inflammation, Immunomodulation,

and Hematopoiesis 747

  1. Introduction to Immunity and Inflammation................................ 749

Michael David

  1. Immunosuppressants, Immunomodulation, and Tolerance ........ 769

Carla V. Rothlin and J. Silvio Gutkind

  1. Immune Globulins and Vaccines..................................................... 793

Roberto Tinoco and James E. Crowe, Jr.

  1. Lipid-Derived Autacoids: Eicosanoids and

Platelet-Activating Factor.................................................................. 815

Emanuela Ricciotti, Tilo Grosser, and Garret A. FitzGerald

  1. Pharmacotherapy of Inflammation, Fever, Pain, and Gout.......... 829

Tilo Grosser, Emanuela Ricciotti, and Garret A. FitzGerald

  1. Histamine, Bradykinin, and Their Antagonists............................. 857

Bruce L. Zuraw and Sandra C. Christiansen

  1. Pulmonary Pharmacology ................................................................ 875

Peter J. Barnes

  1. Hematopoietic Agents: Growth Factors, Minerals,

and Vitamins....................................................................................... 899

Michael Choi and Thomas J. Kipps

Section V

Endocrine Pharmacology 921

  1. Introduction to Endocrinology:

The Hypothalamic-Pituitary Axis.................................................... 923

Dequina A. Nicholas and Mark A. Lawson

  1. Thyroid and Antithyroid Drugs....................................................... 941

Ronald J. Koenig and Gregory A. Brent

  1. Estrogens, Progestins, and the Female Reproductive Tract.......... 959

Ellis R. Levin, Wendy S. Vitek, and Stephen R. Hammes

  1. Androgens and the Male Reproductive Tract ................................ 991

Peter J. Snyder

  1. Adrenocorticotropic Hormone, Adrenal Steroids,

and the Adrenal Cortex...................................................................1003

Christopher J. Hupfeld and Jorge Iñiguez-Lluhí

  1. Endocrine Pancreas and Pharmacotherapy of

Diabetes Mellitus and Hypoglycemia............................................1023

Alvin C. Powers and David D’Alessio

  1. Agents Affecting Mineral Ion Homeostasis

and Bone Turnover..........................................................................1049

Thomas D. Nolin and Peter A. Friedman

Section VI

Gastrointestinal Pharmacology 1071

  1. Pharmacotherapy for Gastric Acidity, Peptic Ulcers, and

Gastroesophageal Reflux Disease...................................................1073

Keith A. Sharkey and Wallace K. MacNaughton

  1. Gastrointestinal Motility and Water Flux, Emesis,

and Biliary and Pancreatic Disease................................................1085

Keith A. Sharkey and Wallace K. MacNaughton

  1. Pharmacotherapy of Inflammatory Bowel Disease .....................1111

Wallace K. MacNaughton and Keith A. Sharkey

Section VII

Chemotherapy of Infectious Diseases 1125 Section Editor: Conan MacDougall

  1. General Principles of Antimicrobial Therapy ..............................1127

Conan MacDougall

  1. DNA Disruptors: Sulfonamides, Quinolones,

and Nitroimidazoles .......................................................................1137

Conan MacDougall

  1. Cell Envelope Disruptors: β-Lactam, Glycopeptide, and

Lipopeptide Antibacterials..............................................................1147

Conan MacDougall

  1. Miscellaneous Antibacterials: Aminoglycosides, Polymyxins,

Urinary Antiseptics, Bacteriophages.............................................1167

Conan MacDougall and Robert T. Schooley

  1. Protein Synthesis Inhibitors ...........................................................1179

Conan MacDougall

  1. Antifungal Agents............................................................................1193
  2. David Rogers and Damian J. Krysan
  3. Antiviral Agents (Nonretroviral)...................................................1211

Edward P. Acosta

  1. Treatment of Viral Hepatitis (HBV/HCV) ...................................1227

Jennifer J. Kiser

  1. Antiretroviral Agents and Treatment of HIV Infection..............1245

Charles W. Flexner

  1. Chemotherapy of Tuberculosis and Nontuberculous

Mycobacteria, Including Leprosy ..................................................1267

Elisa H. Ignatius and Kelly E. Dooley

  1. Chemotherapy of Malaria ...............................................................1289

Abdoulaye A. Djimdé and Steve M. Taylor

  1. Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis,

Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other

Protozoal Infections.........................................................................1309

Dawn M. Wetzel and Margaret A. Phillips

  1. Chemotherapy of Helminth Infections.........................................1325

Jennifer Keiser, James McCarthy, and Peter Hotez

Section VIII

Pharmacotherapy of Neoplastic Disease 1335 Section Editor: Anton Wellstein

  1. General Principles in the Pharmacotherapy of Cancer...............1337

Anton Wellstein

  1. Cytotoxics and Antimetabolites.....................................................1343

Anton Wellstein and Edward A. Sausville

  1. Protein Kinase Inhibitors and Pathway-Targeted

Small Molecules ...............................................................................1381

Anton Wellstein and Giuseppe Giaccone

  1. Antibodies, CAR T Cells, and Proteins to Treat Cancer.............1415

Anton Wellstein and Michael B. Atkins

  1. Hormones, Hormone Receptor Antagonists, and

Related Agents in the Therapy of Cancer.....................................1435

Claudine Isaacs, Kerry L. Burnstein, and Anna T. Riegel

Section IX

Special Systems Pharmacology 1451

  1. Ocular Pharmacology......................................................................1453

Upneet K. Bains, Zeba A. Syed, Jeffrey D. Henderer,

and Christopher J. Rapuano

  1. Dermatological Pharmacology.......................................................1475

Matthew J. Sewell and Dean S. Morrell

  1. Environmental Toxicology..............................................................1507

Allison K. Ehrlich

Appendices

  1. Design and Optimization of Dosage Regimens:

Pharmacokinetic Data .....................................................................1533

Isabelle Ragueneau-Majlessi, Jingjing Yu, and Nina Isoherranen

  1. Drug-Drug Interactions..................................................................1591

Isabelle Ragueneau-Majlessi, Jingjing Yu, and Nina Isoherranen

Index 1595

 

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