- Dedication
- Dedication to William O. Foye
- Preface
- Acknowledgements
- Contributors
- Clinical Contributors
- Contents
- Part I Principles
- Chapter 1 The Evolution of Medicinal Chemistry
- Discovery and Chemistry of Biologically Active Substances
- Evolution From Art to Science
- Biology-Enabled Chemistry and Vice Versa
- Selected Technology-Based Examples of Medicinal Chemistry Development
- Where Will Medicinal Chemistry Be in 2050?
- Summary
- Chapter 2 Foundational Principles and Functional Group Impact on Activity
- Introduction
- Relationship Between Molecular Structure and Biologic Activity
- Selectivity of Drug Action and Drug Receptors
- Physicochemical Properties of Drugs
- Relative Acid Strength (pKa)
- Drug Absorption
- Passive Diffusion
- Active Transport (Influx and Efflux Transporters)
- Prodrugs
- Stereochemistry and Drug Action
- Stereochemical Definitions
- Drug Design: Discovery and Structural Modification of Lead Molecules
- Peptide and Protein Drugs
- Summary
- Acknowledgments
- Chapter 3 Drug Metabolism
- Introduction
- Pathways of Metabolism
- Factors Affecting Metabolism
- Drug Biotransformation Pathway (Phase 1)
- Drug Conjugation Pathways (Phase 2)
- Elimination Pathways
- Drug Metabolism and Age
- Genetic Polymorphism
- First-Pass Metabolism
- Extrahepatic Metabolism
- Stereochemical Aspects of Drug Metabolism
- Metabolic Bioactivation: Role in Hepatotoxicity, Idiosyncratic Reactions
Maintaining its status as the gold standard in medicinal chemistry education, Foye's Principles of Medicinal Chemistry, 9th Edition, presents a renewed focus on the fundamental concepts that form the backbone of this critical discipline. This latest edition, helmed by new senior editors Marc Harrold and Kim Beck, continues the text's legacy of excellence while streamlining content for today's pharmacy students and practitioners. Expert contributions from experienced educators, research scientists, and clinicians clarify the chemical basis of drug action, emphasizing the structure-activity relationships, physicochemical-pharmacokinetic properties, and metabolic profiles of the most commonly used drugs.UPDATED! Focused content emphasizes essential information in an ideal format for contemporary PharmD curricula.
UPDATED! Drug information equips students with the latest developments in drug discovery, structure optimization and clinical use.
Clinical Significance testimonials provide a clinician’s view of the relevance of medicinal chemistry to practice.
End-of-Chapter exercises provide valuable self-assessment opportunities and reinforce key concepts.