Foye's Principles of Medicinal Chemistry

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9781975218720
Precio de lista: COP 457.814 Precio Celsus COP 366.251
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Precio Lista COP 457.814
Precio CELSUS
Precio de lista: COP 457.814 Precio Celsus COP 366.251
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Maintaining its status as the gold standard in medicinal chemistry education, Foye's Principles of Medicinal Chemistry, 9th Edition, presents a renewed focus on the fundamental concepts that form the backbone of this critical discipline. This latest edition, helmed by new senior editors Marc Harrold and Kim Beck, continues the text's legacy of excellence while streamlining content for today's pharmacy students and practitioners. Expert contributions from experienced educators, research scientists, and clinicians clarify the chemical basis of drug action, emphasizing the structure-activity relationships, physicochemical-pharmacokinetic properties, and metabolic profiles of the most commonly used drugs.UPDATED! Focused content emphasizes essential information in an ideal format for contemporary PharmD curricula.
UPDATED! Drug information equips students with the latest developments in drug discovery, structure optimization and clinical use.
Clinical Significance testimonials provide a clinician’s view of the relevance of medicinal chemistry to practice.
End-of-Chapter exercises provide valuable self-assessment opportunities and reinforce key concepts.  

  1. Dedication
  2. Dedication to William O. Foye
  3. Preface
  4. Acknowledgements
  5. Contributors
  6. Clinical Contributors
  7. Contents
  8. Part I Principles
  9. Chapter 1 The Evolution of Medicinal Chemistry
  10. Discovery and Chemistry of Biologically Active Substances
  11. Evolution From Art to Science
  12. Biology-Enabled Chemistry and Vice Versa
  13. Selected Technology-Based Examples of Medicinal Chemistry Development
  14. Where Will Medicinal Chemistry Be in 2050?
  15. Summary
  16. Chapter 2 Foundational Principles and Functional Group Impact on Activity
  17. Introduction
  18. Relationship Between Molecular Structure and Biologic Activity
  19. Selectivity of Drug Action and Drug Receptors
  20. Physicochemical Properties of Drugs
  21. Relative Acid Strength (pKa)
  22. Drug Absorption
  23. Passive Diffusion
  24. Active Transport (Influx and Efflux Transporters)
  25. Prodrugs
  26. Stereochemistry and Drug Action
  27. Stereochemical Definitions
  28. Drug Design: Discovery and Structural Modification of Lead Molecules
  29. Peptide and Protein Drugs
  30. Summary
  31. Acknowledgments
  32. Chapter 3 Drug Metabolism
  33. Introduction
  34. Pathways of Metabolism
  35. Factors Affecting Metabolism
  36. Drug Biotransformation Pathway (Phase 1)
  37. Drug Conjugation Pathways (Phase 2)
  38. Elimination Pathways
  39. Drug Metabolism and Age
  40. Genetic Polymorphism
  41. First-Pass Metabolism
  42. Extrahepatic Metabolism
  43. Stereochemical Aspects of Drug Metabolism
  44. Metabolic Bioactivation: Role in Hepatotoxicity, Idiosyncratic Reactions
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