Pocket Oncology

GENERAL ONCOLOGY 1-1
Julian A. Waksal, Binbin Zheng-Lin, Victoria Blinder, Samuel Freedman,
Jodi Mones
er Epidemiology 1-1
er Prevention & Screening 1-3
ele-Oncology 1-5
CLINICAL RESEARCH METHODS 2-6
Sandeep S. Raj, Alison Schram, Robert Stuver, Martin H. Voss, Xiaodi Wu,
ca Gucalp, Andrew Vickers, Noura Choudhury, Gregory J. Riely
Phase I Clinical Trials 2-6
Phase II and III Clinical Trials 2-8
Biomarker Development 2-10
Biostatistics 2-11
egulatory Aspects of Clinical Trials 2-13
RADIATION ONCOLOGY 3-15
y S. Lebow, Daniel Gomez, Barry S. Rosenstein, N. Ari Wijetunga,
Simon N. Powell, Christopher H. Crane, Patricia Mae G. Santos,
Neil K. Taunk, Michael J. Zelefsky, Brandon S. Imber,
Daniel S. Higginson, Yoshiya (Josh) Yamada
Basic Radiation Biology and Physics 3-15
nal Beam Radiation Therapy 3-17
tactic Radiotherapy 3-19
ytherapy 3-21
TBI and TSEB 3-23
adiation Oncology Emergencies 3-25
PRINCIPLES OF SURGERY AND
INTERVENTIONAL ONCOLOGY 4-28
. Lee, Michael I. D’Angelica, Alice Chia-chi Wei, Vibhor Wadhwa,
nesto Santos, Etay Ziv, An Thi Nhat Ho, Varun Shah, Robert P. Lee,
Mohit Chawla
iples of Surgical Oncology 4-28
Surgical Emergencies 4-29
entional Pulmonology 4-31
entional Radiology Introduction 4-34
ransarterial Therapies 4-35
Image-Guided Percutaneous Ablation 4-36
uloskeletal Interventions 4-37
entional Radiology Emergencies 4-38
CANCER BIOLOGY 5-40
Lauren Baker Banks, Juan C. Osorio, Ezra Rosen, Yonit Lavin,
aruna Ganesh, Jessie Bourcier, Michelangelo Marasco, Rona Yaeger, Transcription, Apoptosis, and TP53 5-44
DNA Repair and Angiogenesis 5-45
MOLECULAR DIAGNOSTICS 6-46
Tony El Jabbour, Omar Abdel-Wahab, Abhinita S. Mohanty,
Jason E. Chan, Sydney X. Lu, Ryma Benayed
Sequencing 6-46
Cytogenetics 6-47
RNA Sequencing 6-49
CANCER IMMUNOLOGY 7-50
Juan C. Osorio, Lauren Baker Banks, Alexander M. Lesokhin,
David Knorr, Christopher A. Klebanoff, Susan Ehrenkranz De Wolf,
Michael Postow, Adam J. Schoenfeld
Cancer Immunobiology 7-50
Immunoregulatory Antibody Therapy 7-52
Toxicities of Immune Checkpoint Inhibitors 7-53
Miscellaneous Immunotherapies 7-55
CAR T-Cell Therapy 7-57
Tumor Infiltrating Lymphocytes (TILs) 7-58
CANCER GENETICS 8-59
Viswatej Avutu, Zsofia K. Stadler, Kelsey Breen
Principles of Hereditary Cancer Syndromes
and Hereditary Breast and Ovarian Cancers 8-59
Lynch Syndrome 8-61
Familial Adenomatous Polyposis (FAP) 8-62
Li–Fraumeni Syndrome 8-63
Other Genetic Syndromes 8-64
CANCER PHARMACOLOGY 9-66
Amber C. King, Josiah D. Land, Dazhi Liu, Tim Peterson,
Samantha N. Reiss, Grashma Vadakkel, Stephen Eng, Terry Pak,
Nicole Daukshus, Krisoula H. Spatz, Andréa LeVoir, Michael J. Buege,
Taylor M. Weis, Jillian Gutierrez
Pharmacogenetics and Pharmacogenomics 9-66
Antibody Drug Conjugates 9-68
Monoclonal Antibodies 9-70
Antimetabolites 9-75
Alkylating Agents 9-79
Antimicrotubular Agents 9-84
Antitumor Antibiotics 9-86
Topoisomerase Inhibitors 9-88
Immunomodulators/Epigenetic Modifiers 9-90
Small Molecule Pathway Inhibitors 9-93
Hormonal Agents 9-107
Bone-Modifying Agents 9-111
Novel Oral Anticoagulants (NOAC) 9-113umor Lysis Syndrome 10-119
Metabolic Emergencies 10-121
yndrome 10-123
Spinal Cord Compression 10-125
or On-Call Fellows 10-127
ALLIATIVE AND SUPPORTIVE CARE 11-128
er A. Salant, Stacy Stabler, Ramy Sedhom, Anjali Varma Desai,
young Erin Jeun, Natalie Moryl, Samantha Francis, Andreana Kwon,
an Jatwani, Reggie T. Saldivar, Viswatej Avutu, Katherine Thornton,
Andrew D. Hunter, Armin Shahrokni, Shilpa S. Lad, Martin S. Chin
iples of Palliative Care 11-128
ain Medications 11-130
Nonpain Symptom Management 11-132
Malignant Bowel Obstruction and TPN 11-135
Adolescent and Young Adult Oncology 11-137
Older Adult Oncology 11-138
ho-Oncology 11-139
CANCER SURVIVORSHIP AND
TILITY PRESERVATION 12-141
Lauren Martino, Jennifer Gorelov, Matthew Matasar
er Survivorship 12-141
tility Preservation 12-144
INFECTIOUS DISEASE 13-146
Mario D. Caldararo, Marilia Bernardes, Monika K. Shah,
Cesar J. Figueroa Ortiz
The High-Risk Oncology Patient 13-146
ections in the Transplant Host 13-149
VID-19 and Cancer 13-151
GENITOURINARY MALIGNANCIES 14-152
Niamh M. Keegan, Maria Carlo, Howard I. Scher, Brendan J. Guercio,
Samuel A. Funt, Kelly N. Fitzgerald, Chung-Han Lee, Michael Lattanzi,
Dean Bajorin
Localized Prostate Cancer 14-152
rent/Metastatic Prostate Cancer 14-154
Bladder Cancer 14-156
enal Cell Carcinoma (RCC) 14-158
m Cell Tumors 14-161
enile Cancer 14-163
THORACIC MALIGNANCIES 15-164
, Mark G. Kris, Philip Choi, W. Victoria Lai, Noura Choudhury,
gory J. Riely, Michael Offin, Marjorie G. Zauderer
Non-Small Cell Lung Cancers 15-164
Small Cell Lung Cancer 15-167Nitya Raj, Diane Reidy-Lagunes, Ryan Moy, Yelena Y. Janjigian,
Melissa Amy Lumish, Andrea Cercek, Salvador Alonso Martinez,
Neil H. Segal, Yonit Lavin, Anna M. Varghese
Hepatocellular Carcinoma (HCC) 16-173
Cancer of the Biliary Tree 16-175
Pancreatic Cancer 16-177
Pancreatic and GI Neuroendocrine Neoplasms 16-179
Esophageal Cancer 16-181
Gastric Cancer 16-183
Appendix and Small Bowel Carcinoma 16-186
Colon Cancer 16-187
Rectal Cancer 16-189
Anal Cancer 16-191
Cancer of Unknown Primary (CUP) 16-193
SKIN CANCERS AND SARCOMAS 17-195
Ryan Q. Notti, William D. Tap, Jonathan Kentley, Allan Halpern,
James W. Smithy, Paul Chapman
Basal and Squamous Cell Carcinomas 17-195
Melanoma 17-197
Soft Tissue Sarcomas (STS) 17-199
Gastrointestinal Stromal Tumor 17-201
Bone Sarcomas 17-203
Ewing Sarcoma Family (ESFT) 17-205
HEAD AND NECK MALIGNANCIES 18-207
Bharat Burman, Lara Dunn, Anupriya Singhal, Alan L. Ho
Head & Neck Squamous Cell Cancer 18-207
Nasopharyngeal Carcinoma 18-209
Salivary Gland Tumors 18-210
ENDOCRINE MALIGNANCIES 19-211
Duaa H. Al-Rawi, Laura Boucai, Eliza B. Geer, Priya Jaisinghani,
Binbin Zheng-Lin, Sapir Nachum
Thyroid Cancer 19-211
Sellar Tumors 19-213
Pheochromocytomas and MEN Syndrome 19-216
Tumors of the Adrenal Cortex 19-219
GYNECOLOGIC MALIGNANCIES 20-221
Melissa Amy Lumish; Maria Rubinstein, Duaa H. Al-Rawi,
Olga T. Filippova, Roisin E. O’Cearbhail, Sushmita Gordhandas,
Rachel N. Grisham, William A. Zammarrelli III, Lea A. Moukarzel,
William P. Tew
Ovarian Cancer 20-221
Ovarian Germ Cell Tumors 20-223
Endometrial Carcinoma 20-225BREAST CANCER 21-233
Anton Safonov, Devika Gajria, Emanuela Ferraro, Tiffany A. Traina,
Joshua Z. Drago, Chau Dang
east Cancer: Introduction 21-233
Localized Breast Cancer 21-235
Metastatic Breast Cancer 21-237
NEUROLOGICAL ONCOLOGY 22-239
th Anne Coffee, Kevin B. Elmore, Maria Diaz,
Thomas J. Kaley, Jessica A. Wilcox
w-Grade Glioma 22-239
High-Grade Glioma 22-241
CNS Metastatic Disease 22-243
araneoplastic Syndromes 22-245
YMPHOMAS 23-247
ander P. Boardman, Robert Stuver, Santosha A. Vardhana,
Alison Moskowitz, Beatriz Wills, Gilles Salles, David Qualls,
a Noy, Robert Stuver, Anita Kumar, Zachary Epstein-Peterson,
Erel Joffe, Steven Horwitz, Christian Grommes
Hodgkin Lymphoma 23-247
ular Lymphoma 23-249
Marginal Zone Lymphoma (MZL) 23-251
Mantle Cell Lymphoma 23-253
use Large B-Cell Lymphoma 23-255
itt Lymphoma 23-257
eripheral T-Cell Lymphoma 23-259
Cutaneous T-Cell Lymphoma 23-261
Primary CNS Lymphoma 23-263
PLASMA CELL DISORDERS 24-265
Xiaodi Wu, Malin Hultcrantz, Robert Stanley, Kylee Maclachlan,
Sandeep S. Raj, M. Lia Palomba, Heather Landau
MGUS and Multiple Myeloma (MM) 24-265
aldenström Macroglobulinemia 24-270
yloidosis 24-272
MYELOPROLIFERATIVE DISORDERS 25-274
imilian Stahl, Varun Narendra, Martin S. Tallman,
hael J. Mauro, Aaron James Stonestrom, Raajit K. Rampal
Essential Thrombocythemia 25-274
ythemia Vera (PV) 25-276
elofibrosis 25-278
Mastocytosis/Hypereosinophilic Syndrome 25-280Omar Abdel-Wahab, Aaron D. Goldberg, Susan Ehrenkranz De Wolf,
Jae H. Park, Mark Blaine Geyer, Michael J. Mauro, Meghan C. Thompson,
Anthony Rocco Mato, Aaron James Stonestrom, Ross Levine
Myelodysplastic Syndromes 26-282
Acute Myeloid Leukemia (AML) 26-284
Acute Lymphoblastic Leukemia/Lymphoma 26-288
Chronic Myelogenous Leukemia (CML) 26-290
Chronic Lymphocytic Leukemia (CLL) 26-292
Hairy Cell and Prolymphocytic Leukemia 26-295
Clonal Hematopoiesis (CH) 26-297
STEM CELL TRANSPLANTATION 27-298
Mariam T. Nawas, Michael Scordo, Christina Cho
Autologous Stem Cell Transplantation 27-298
Allogeneic Stem Cell Transplantation 27-300
BENIGN HEMATOLOGY 28-303
Beatriz Wills, Mariam T. Nawas, Rekha Paramesawaran,
Varun Narendra, Sheng F. Cai, Aaron James Stonestrom,
Simon Mantha, Meghan C. Thompson, Ioannis Politikos, Jodi Mones,
Robert Stuver, Melody Smith, Zachary Epstein-Peterson, Cy R. Wilkins,
Alexandra Budhai, Maly Fenelus
Biology of Hematopoiesis 28-303
Anemias of Underproduction 28-305
Hemolytic Anemias 28-307
Hemoglobinopathies 28-310
Hypercoagulable States 28-312
Porphyrias 28-314
Bleeding Diatheses 28-315
Platelet Disorders 28-318
Transfusion Medicine 28-321
Screening Tests in Hemostasis 28-323
PEDIATRIC CANCERS 29-326
Christina Fong, Allyson Flower, Alexandre G. Troullioud Lucas,
Jaclyn Rosenzweig, Maria Luisa Sulis, Sheila S. McThenia,
Sameer Farouk Sait, Morgan Pines, Michael Kinnaman,
Carly Rosemore, Emily K. Slotkin, Jessica Stiefel, Fiorella Iglesias Cardenas,
Melanie Degliuomini, Michael V. Ortiz, Ira J. Dunkel, Zahra Hudda,
Julia Glade Bender, Madhavi Lakkaraja, María I. Cancio, Sanam Shahid,
Barbara Spitzer
General Pediatric Considerations 29-326
Pediatric Oncologic Emergencies 29-328
Pediatric Hematologic Malignancies 29-330
Bone Marrow Failure Syndromes 29-334
Transplant and Cellular Therapy 29-337
Central Nervous System Malignancies 29-340etinoblastoma (RB) 29-349
m Cell Tumors 29-350
OR PHOTOS 351
ter Maslak, Alyce M. Kuo, Mario Lacouture
eripheral Blood Smears and Bone Marrow Aspirates/Biopsies 351
matologic Adverse Events from Anticancer Therapies 359
APPENDICES 367
w R. Kudelka, Yonina R. Murciano-Goroff, Michael Postow,
andhara Kate, Stacy Stabler, Anna M. Varghese,
tt Millman
mance Score Measures 367
adiographic Response Criteria 368
Quality of Life Assessments 369
umor Markers 371
ming BM Biopsy/Aspirate 373
ABBREVIATIONS 374
INDEX 388